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Various factors influence the likelihood of developing gallstones, including age and genderwomen are more susceptible than men, particularly during pregnancies and hormonal changes, increased body mass index and obesity promote cholesterol supersaturation in bile, and non-alcoholic fatty liver disease (NAFLD) contributes to impaired bile flow [5]

The endogenous expression of CTLA-4 on the pituitary can also lead to hypophysitis

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Cost and accessibility are also important factors

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